منابع مشابه
Sympatho-adrenal activation by chronic intermittent hypoxia.
Recurrent apnea with chronic intermittent hypoxia (CIH) is a major clinical problem in adult humans and infants born preterm. Patients with recurrent apnea exhibit heightened sympathetic activity as well as elevated plasma catecholamine levels, and these phenotypes are effectively recapitulated in rodent models of CIH. This article summarizes findings from studies addressing sympathetic activat...
متن کاملKlotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease.
BACKGROUND Membrane αKlotho (hereinafter called Klotho) is highly expressed in the kidney and functions as a coreceptor of FGF receptors (FGFRs) to activate specific fibroblast growth factor 23 (FGF23) signal pathway. FGF23 is produced in bones and participates in the maintenance of mineral homeostasis. The extracellular domain of transmembrane Klotho can be cleaved by secretases and released i...
متن کاملHIGHLIGHTED TOPIC Mechanisms of Sympathetic Regulation in Cardiovascular Disease Sympatho-adrenal activation by chronic intermittent hypoxia
Prabhakar NR, Kumar GK, Peng Y-J. Sympatho-adrenal activation by chronic intermittent hypoxia. J Appl Physiol 113: 1304–1310, 2012. First published June 21, 2012; doi:10.1152/japplphysiol.00444.2012.—Recurrent apnea with chronic intermittent hypoxia (CIH) is a major clinical problem in adult humans and infants born preterm. Patients with recurrent apnea exhibit heightened sympathetic activity a...
متن کاملThe Chronic Kidney Disease - Colonic Axis.
Chronic kidney disease (CKD) has long been known to cause significant gastrointestinal and colonic pathology. Recent advances in understanding of the role of colonic bacterial microbiome and its function and composition in health and disease have revealed previously unappreciated effects of CKD-associated colonic pathology on the development of uremic complications. CKD can result in profound c...
متن کاملChronic Renal Disease: Orthomolecular Ramifications
Introduction Increasingly, human kidneys are under assault from environmental toxins as well as an array of diseases that place them at risk of ultimately failing. Eleven percent of American adults now show evidence of chronic kidney disease, with over 400,000 afflicted with end-stage kidney disease. Over a third of those cases are caused by diabetes, and the remainder by high blood pressure an...
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ژورنال
عنوان ژورنال: Clinical Research in Cardiology
سال: 2011
ISSN: 1861-0684,1861-0692
DOI: 10.1007/s00392-011-0335-y